Discovery of [5,5'-bibenzo[d][1,3]dioxol]-6-substituted amine derivatives as potent proprotein convertase subtilisin/kexin type 9 inhibitors.

Zhu, Dongqi; Qin, Hongyu; Wang, Xiaojing; Jia, Yuping; Wang, Xuejian; Zhang, Lei

Zhu, Dongqi; Qin, Hongyu; Wang, Xiaojing; Jia, Yuping; Wang, Xuejian; Zhang, Lei.

Afiliación

Zhu D; Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China.
Qin H; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Wang X; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Jia Y; Shandong Academy of Pharmaceutical Science, Jinan, China.
Wang X; Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.

Chem Biol Drug Des ; 102(1): 153-167, 2023 07.

Article en En | MEDLINE | ID: mdl-37170061

Asunto(s)

Hiperlipidemias; Proproteína Convertasa 9; Humanos; Proproteína Convertasa 9/química; Receptores de LDL/metabolismo; Simulación del Acoplamiento Molecular; Células Hep G2; Hiperlipidemias/tratamiento farmacológico; Subtilisinas

Palabras clave

LDLR; PCSK9; PPI inhibitor; hyperlipidemia; structural modification

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proproteína Convertasa 9 / Hiperlipidemias Límite: Humans Idioma: En Revista: Chem Biol Drug Des Asunto de la revista: BIOQUIMICA / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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