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Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity.
Ji, Tangyang; Jian, Xieer; Chen, Lin; Zeng, Wenbin; Huo, Xiansen; Li, Mingxia; Chen, Peng; Zhang, Yuqi; You, Wenwei; Zhao, Peiliang.
Afiliación
  • Ji T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Jian X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Chen L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zeng W; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Huo X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Li M; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Chen P; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zhang Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • You W; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
  • Zhao P; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: plzhao@smu.edu.cn.
Eur J Med Chem ; 256: 115437, 2023 Aug 05.
Article en En | MEDLINE | ID: mdl-37172475
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiadiazinas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiadiazinas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article