The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain.
J Infect
; 87(2): 103-110, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37178807
ABSTRACT
BACKGROUND:
Human metapneumovirus (HMPV) is an important aetiologic agent of respiratory tract infection (RTI). This study aimed to describe the prevalence, genetic diversity, and evolutionary dynamics of HMPV.METHODS:
Laboratory-confirmed HMPV were characterised based on partial-coding G gene sequences with MEGA.v6.0. WGS was performed with Illumina, and evolutionary analyses with Datamonkey and Nextstrain.RESULTS:
HMPV prevalence was 2.5%, peaking in February-April and with an alternation in the predominance of HMPV-A and -B until the emergence of SARS-CoV-2, not circulating until summer and autumn-winter 2021, with a higher prevalence and with the almost only circulation of A2c111dup. G and SH proteins were the most variable, and 70% of F protein was under negative selection. Mutation rate of HMPV genome was 6.95 × 10-4 substitutions/site/year.CONCLUSION:
HMPV showed a significant morbidity until the emergence of SARS-CoV-2 pandemic in 2020, not circulating again until summer and autumn 2021, with a higher prevalence and with almost the only circulation of A2c111dup, probably due to a more efficient immune evasion mechanism. The F protein showed a very conserved nature, supporting the need for steric shielding. The tMRCA showed a recent emergence of the A2c variants carrying duplications, supporting the importance of virological surveillance.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Infecciones por Paramyxoviridae
/
Metapneumovirus
/
COVID-19
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Infant
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Infect
Año:
2023
Tipo del documento:
Article
País de afiliación:
España