Your browser doesn't support javascript.
loading
Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish.
Park, Junho; An, Garam; Park, Hahyun; Hong, Taeyeon; Lim, Whasun; Song, Gwonhwa.
Afiliación
  • Park J; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • An G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • Park H; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • Hong T; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Lim W; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: wlim@skku.edu.
  • Song G; Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address: ghsong@korea.ac.kr.
Environ Int ; 176: 107973, 2023 06.
Article en En | MEDLINE | ID: mdl-37196567
ABSTRACT
Thiabendazole, a benzimidazole fungicide, is widely used to prevent yield loss in agricultural land by inhibiting plant diseases derived from fungi. As thiabendazole has a stable benzimidazole ring structure, it remains in the environment for an extended period, and its toxic effects on non-target organisms have been reported, indicating the possibility that it could threaten public health. However, little research has been conducted to elucidate the comprehensive mechanisms of its developmental toxicity. Therefore, we used zebrafish, a representative toxicological model that can predict toxicity in aquatic organisms and mammals, to demonstrate the developmental toxicity of thiabendazole. Various morphological malformations were observed, including decreased body length, eye size, and increased heart and yolk sac edema. Apoptosis, reactive oxygen species (ROS) production, and inflammatory response were also triggered by thiabendazole exposure in zebrafish larvae. Furthermore, PI3K/Akt and MAPK signaling pathways important for appropriate organogenesis were significantly changed by thiabendazole. These results led to toxicity in various organs and a reduction in the expression of related genes, including cardiovascular toxicity, neurotoxicity, and hepatic and pancreatic toxicity, which were detected in flk1eGFP, olig2dsRED, and L-fabpdsRed;elastaseGFP transgenic zebrafish models, respectively. Overall, this study partly determined the developmental toxicity of thiabendazole in zebrafish and provided evidence of the environmental hazards of this fungicide.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_quimicos_contaminacion Asunto principal: Contaminantes Químicos del Agua / Fungicidas Industriales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Int Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 Problema de salud: 2_quimicos_contaminacion Asunto principal: Contaminantes Químicos del Agua / Fungicidas Industriales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Int Año: 2023 Tipo del documento: Article
...