No food for thought: an intermediate level of food deprivation enhances memory in Lymnaea stagnalis.
J Exp Biol
; 226(10)2023 05 15.
Article
en En
| MEDLINE
| ID: mdl-37232484
ABSTRACT
Nutritional status plays an important role in cognitive functioning, but there is disagreement on the role that food deprivation plays in learning and memory. In this study, we investigated the behavioral and transcriptional effects induced by different lengths of food deprivation 1â
day, which is a short time period of food deprivation, and 3â
days, which is an 'intermediate' level of food deprivation. Snails were subjected to different feeding regimens and then trained for operant conditioning of aerial respiration, where they received a single 0.5â
h training session followed by a long-term memory (LTM) test 24â
h later. Immediately after the memory test, snails were killed and the expression levels of key genes for neuroplasticity, energy balance and stress response were measured in the central ring ganglia. We found that 1â
day of food deprivation was not sufficient to enhance snails' LTM formation and subsequently did not result in any significant transcriptional effects. However, 3â
days of food deprivation resulted in enhanced LTM formation and caused the upregulation of neuroplasticity and stress-related genes and the downregulation of serotonin-related genes. These data provide further insight into how nutritional status and related molecular mechanisms impact cognitive function.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aprendizaje
/
Lymnaea
Límite:
Animals
Idioma:
En
Revista:
J Exp Biol
Año:
2023
Tipo del documento:
Article