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AIF1: Function and Connection with Inflammatory Diseases.
De Leon-Oliva, Diego; Garcia-Montero, Cielo; Fraile-Martinez, Oscar; Boaru, Diego Liviu; García-Puente, Luis; Rios-Parra, Antonio; Garrido-Gil, Maria J; Casanova-Martín, Carlos; García-Honduvilla, Natalio; Bujan, Julia; Guijarro, Luis G; Alvarez-Mon, Melchor; Ortega, Miguel A.
Afiliación
  • De Leon-Oliva D; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Garcia-Montero C; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • Fraile-Martinez O; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Boaru DL; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • García-Puente L; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Rios-Parra A; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • Garrido-Gil MJ; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Casanova-Martín C; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • García-Honduvilla N; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Bujan J; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • Guijarro LG; Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
  • Alvarez-Mon M; Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
  • Ortega MA; Cancer Registry and Pathology Department, Principe de Asturias University Hospital, 28806 Alcala de Henares, Spain.
Biology (Basel) ; 12(5)2023 May 09.
Article en En | MEDLINE | ID: mdl-37237507
ABSTRACT
Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biology (Basel) Año: 2023 Tipo del documento: Article País de afiliación: España
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biology (Basel) Año: 2023 Tipo del documento: Article País de afiliación: España