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The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates.
Chaudhary, Shefali; Chen, Yu; Zhornitsky, Simon; Le, Thang M; Zhang, Sheng; Chao, Herta H; Dominguez, Jacqueline C; Li, Chiang-Shan R.
Afiliación
  • Chaudhary S; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Chen Y; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Zhornitsky S; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Le TM; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Zhang S; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Chao HH; VA Connecticut Healthcare System, West Haven, CT, USA.
  • Dominguez JC; Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Li CR; St. Luke's Medical Center, Quezon City, Metro Manila, Philippines.
Addict Biol ; 28(6): e13278, 2023 06.
Article en En | MEDLINE | ID: mdl-37252876
ABSTRACT
Aging is associated with reduction in the severity of alcohol misuse. However, the psychological and neural mechanisms underlying the age-related changes remain unclear. Here, we tested the hypothesis that age-related diminution of positive alcohol expectancy (AE) mediated the effects of age on problem drinking and investigated the neural correlates of the mediating effects. Ninety-six drinkers 21-85 years of age, including social drinkers and those with mild/moderate alcohol use disorder (AUD), were assessed for global positive (GP) AE and problem drinking, each with the Alcohol Expectancy Questionnaire and Alcohol Use Disorders Identification Test (AUDIT), and with brain imaging during alcohol cue exposure. We processed imaging data with published routines; identified the correlates shared between whole-brain regression against age, GP and AUDIT scores; and performed mediation and path analyses to explore the interrelationships between the clinical and neural variables. The results showed that age was negatively correlated with both GP and AUDIT scores, with GP score completely mediating the correlation between age and AUDIT score. Lower age and higher GP correlated with shared cue responses in bilateral parahippocampal gyrus and left middle occipital cortex (PHG/OC). Further, higher GP and AUDIT scores were associated with shared cue responses in bilateral rostral anterior cingulate cortex and caudate head (ACC/caudate). Path analyses demonstrated models with significant statistical fit and PHG/OC and ACC/caudate each interrelating age to GP and GP to AUDIT scores. These findings confirmed change in positive AE as a psychological mechanism mitigating alcohol misuse as individuals age and highlighted the neural processes of cue-reactivity interrelating age and alcohol use severity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Problema de salud: 2_sustancias_psicoativas / 8_alcohol Asunto principal: Alcoholismo Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Problema de salud: 2_sustancias_psicoativas / 8_alcohol Asunto principal: Alcoholismo Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Addict Biol Asunto de la revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
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