Your browser doesn't support javascript.
loading
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls.
Zheng, Bang; Vivaldi, Giulia; Daines, Luke; Leavy, Olivia C; Richardson, Matthew; Elneima, Omer; McAuley, Hamish J C; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Saunders, Ruth M; Harris, Victoria C; Houchen-Wolloff, Linzy; Greening, Neil J; Pfeffer, Paul E; Hurst, John R; Brown, Jeremy S; Shankar-Hari, Manu; Echevarria, Carlos; De Soyza, Anthony; Harrison, Ewen M; Docherty, Annemarie B; Lone, Nazir; Quint, Jennifer K; Chalmers, James D; Ho, Ling-Pei; Horsley, Alex; Marks, Michael; Poinasamy, Krishna; Raman, Betty; Heaney, Liam G; Wain, Louise V; Evans, Rachael A; Brightling, Christopher E; Martineau, Adrian; Sheikh, Aziz.
Afiliación
  • Zheng B; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Vivaldi G; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Daines L; Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Leavy OC; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Richardson M; Department of Population Health Sciences, University of Leicester, Leicester, UK.
  • Elneima O; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • McAuley HJC; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Shikotra A; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Singapuri A; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Sereno M; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Saunders RM; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Harris VC; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Houchen-Wolloff L; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Greening NJ; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Pfeffer PE; University Hospitals of Leicester NHS Trust, Leicester, UK.
  • Hurst JR; Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
  • Brown JS; Therapy Department, University Hospitals of Leicester, NHS Trust, Leicester, UK.
  • Shankar-Hari M; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Echevarria C; Barts Health NHS Trust, London, UK.
  • De Soyza A; Queen Mary University of London, London, UK.
  • Harrison EM; UCL Respiratory, University College London, London, UK.
  • Docherty AB; UCL Respiratory, University College London, London, UK.
  • Lone N; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
  • Quint JK; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
  • Chalmers JD; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
  • Ho LP; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
  • Horsley A; Population Health Science Institute, Newcastle University, Newcastle, UK.
  • Marks M; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Poinasamy K; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Raman B; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Heaney LG; Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK.
  • Wain LV; National Heart Lung Institute, Imperial College London, London, UK.
  • Evans RA; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
  • Brightling CE; Medical Research Council (MRC) Human Immunology Unit, University of Oxford, Oxford, UK.
  • Martineau A; Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Sheikh A; Manchester University NHS Foundation Trust, Manchester, UK.
Lancet Reg Health Eur ; 29: 100635, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37261214
ABSTRACT

Background:

The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea.

Methods:

We used data from two prospective cohort studies PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up.

Findings:

We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01-1.03), male (1.54, 1.16-2.04), neither obese nor severely obese (1.82, 1.06-3.13 and 4.19, 2.14-8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09-2.22) or cardiovascular disease (1.33, 1.00-1.79), and shorter hospital admission (1.01 per day, 1.00-1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission).

Interpretation:

Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19.

Funding:

PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care.COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis / 1_geracao_evidencia_conhecimento Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Lancet Reg Health Eur Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis / 1_geracao_evidencia_conhecimento Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Lancet Reg Health Eur Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido