Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets.
J Neurosci Res
; 101(10): 1538-1554, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37272728
ABSTRACT
Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central nervous system; it imposes great psychological and economic burdens on affected patients and their families. The dynamic balance between reactive oxygen species (ROS) and antioxidants is essential for maintaining normal cellular physiological functions. As important intracellular signaling molecules, ROS regulate numerous physiological activities, including vascular reactivity and neuronal function. However, excessive ROS can cause damage to cellular macromolecules, including DNA, lipids, and proteins; this damage eventually leads to cell death. This review discusses the mechanisms of oxidative stress in SCI and describes some signaling pathways that regulate oxidative injury after injury, with the aim of providing guidance for the development of novel SCI treatment strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Estrés Oxidativo
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
J Neurosci Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China