Altered fear engram encoding underlying conditioned versus unconditioned stimulus-initiated memory updating.
Sci Adv
; 9(23): eadf0284, 2023 06 09.
Article
en En
| MEDLINE
| ID: mdl-37285430
ABSTRACT
It is known that post-retrieval extinction but not extinction alone could erase fear memory. However, whether the coding pattern of original fear engrams is remodeled or inhibited remains largely unclear. We found increased reactivation of engram cells in the prelimbic cortex and basolateral amygdala during memory updating. Moreover, conditioned stimulus- and unconditioned stimulus-initiated memory updating depends on the engram cell reactivation in the prelimbic cortex and basolateral amygdala, respectively. Last, we found that memory updating causes increased overlapping between fear and extinction cells, and the original fear engram encoding was altered during memory updating. Our data provide the first evidence to show the overlapping ensembles between fear and extinction cells and the functional reorganization of original engrams underlying conditioned stimulus- and unconditioned stimulus-initiated memory updating.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complejo Nuclear Basolateral
/
Memoria
Idioma:
En
Revista:
Sci Adv
Año:
2023
Tipo del documento:
Article