Base-Promoted [5 + 1 + 3] Cascade Cyclization of o-Nitrochalcones, Elemental Sulfur, and Guanidine to Benzo[4,5]thieno[3,2-d]pyrimidine Frameworks.
Org Lett
; 25(24): 4451-4455, 2023 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-37294057
ABSTRACT
An unexpected [5 + 1 + 3] cascade cyclization to the preparation of benzo[4,5]thieno[3,2-d]pyrimidine derivatives has been disclosed. In the new protocol, o-nitrochalcones reacted with elemental sulfur and guanidine promoted by NaOH, which reacted in EtOH for 20 min, providing structurally diverse benzo[4,5]thieno[3,2-d]pyrimidines with good yields (77-89%) and wide substrate compatibility (33 examples).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Guanidinas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2023
Tipo del documento:
Article