Inhibitors of Aspartate Transcarbamoylase Inhibit Mycobacterium tuberculosis Growth.

Du, Xiaochen; Sonawane, Vidhisha; Zhang, Bidong; Wang, Chao; de Ruijter, Bram; Dömling, Alexander S S; Reiling, Norbert; Groves, Matthew R

Du, Xiaochen; Sonawane, Vidhisha; Zhang, Bidong; Wang, Chao; de Ruijter, Bram; Dömling, Alexander S S; Reiling, Norbert; Groves, Matthew R.

Afiliación

Du X; XB20 Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9700AV (The, Netherlands.
Sonawane V; CATRIN, Department of Innovative Chemistry, PalackÈ³University, 779 00, Olomouc - Holice, Czech Republic.
Zhang B; XB20 Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9700AV (The, Netherlands.
Wang C; XB20 Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9700AV (The, Netherlands.
de Ruijter B; XB20 Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9700AV (The, Netherlands.
Dömling ASS; XB20 Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9700AV (The, Netherlands.
Reiling N; CATRIN, Department of Innovative Chemistry, PalackÈ³University, 779 00, Olomouc - Holice, Czech Republic.
Groves MR; RG Microbial Interface Biology, Research Center Borstel Leibniz Lung Center, Parkallee 1-40, Borstel, 23845, Sülfeld, Germany.

ChemMedChem ; 18(17): e202300279, 2023 09 01.

Article en En | MEDLINE | ID: mdl-37294060

Asunto(s)

Escherichia coli; Mycobacterium tuberculosis; Humanos; Ácido Aspártico

Palabras clave

Mycobacterium tuberculosis; allosteric inhibition; aspartate transcarbamoylase; molecular docking; pyrimidine biosynthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_tuberculosis / 3_zoonosis Asunto principal: Escherichia coli / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

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