Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects.
Best Pract Res Clin Anaesthesiol
; 37(1): 40-51, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-37295853
ABSTRACT
Pre-clinical experimental evidence, along with a plausible biological rational suggests that exposure of neonates and young children to anesthesia may harm brain development. However, the translational relevance of these observations remains unsolved. While a variety of lasting morpho-functional effects can be attributed to early life exposure to anesthetics in laboratory animals, we do not have a convincing human phenotype that reflects any causal effects of general anesthetic exposure on brain development and functional outcome. This review is aimed to provide a comprehensive description of the current state of clinical research alongside exploring future challenges in this field by focusing on the critical appraisal of methodological approaches applied in clinical research into developmental anesthesia neurotoxicity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndromes de Neurotoxicidad
/
Anestésicos
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Child
/
Child, preschool
/
Humans
/
Newborn
Idioma:
En
Revista:
Best Pract Res Clin Anaesthesiol
Asunto de la revista:
ANESTESIOLOGIA
Año:
2023
Tipo del documento:
Article