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Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out Of Uniformity and Uniqueness Behind Uniformity.
Ono, Eiichiro; Murata, Jun.
Afiliación
  • Ono E; Suntory Global Innovation Center Ltd. (SIC), 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284 Japan.
  • Murata J; Bioorganic Research Institute (SUNBOR), Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284 Japan.
Plant Cell Physiol ; 64(12): 1449-1465, 2023 Dec 21.
Article en En | MEDLINE | ID: mdl-37307423
The huge structural diversity exhibited by plant specialized metabolites has primarily been considered to result from the catalytic specificity of their biosynthetic enzymes. Accordingly, enzyme gene multiplication and functional differentiation through spontaneous mutations have been established as the molecular mechanisms that drive metabolic evolution. Nevertheless, how plants have assembled and maintained such metabolic enzyme genes and the typical clusters that are observed in plant genomes, as well as why identical specialized metabolites often exist in phylogenetically remote lineages, is currently only poorly explained by a concept known as convergent evolution. Here, we compile recent knowledge on the co-presence of metabolic modules that are common in the plant kingdom but have evolved under specific historical and contextual constraints defined by the physicochemical properties of each plant specialized metabolite and the genetic presets of the biosynthetic genes. Furthermore, we discuss a common manner to generate uncommon metabolites (uniqueness out of uniformity) and an uncommon manner to generate common metabolites (uniqueness behind uniformity). This review describes the emerging aspects of the evolvability of plant specialized metabolism that underlie the vast structural diversity of plant specialized metabolites in nature.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas / Redes y Vías Metabólicas Idioma: En Revista: Plant Cell Physiol Asunto de la revista: BOTANICA Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas / Redes y Vías Metabólicas Idioma: En Revista: Plant Cell Physiol Asunto de la revista: BOTANICA Año: 2023 Tipo del documento: Article
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