Design and Pharmacological Chaperone Effects of <i>N</i>-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid &#945;-Glucosidase.

Kato, Atsushi; Nakagome, Izumi; Kise, Maki; Yoshimura, Kousuke; Tanaka, Nobutada; Nash, Robert J; Fleet, George W J; Kobayashi, Yota; Ikeda, Hayato; Okada, Takuya; Toyooka, Naoki

Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.

Kato, Atsushi; Nakagome, Izumi; Kise, Maki; Yoshimura, Kousuke; Tanaka, Nobutada; Nash, Robert J; Fleet, George W J; Kobayashi, Yota; Ikeda, Hayato; Okada, Takuya; Toyooka, Naoki.

Afiliación

Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Nakagome I; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Kise M; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Yoshimura K; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Tanaka N; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Nash RJ; Institute of Biological, Environmental and Rural Sciences / Phytoquest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, U.K.
Fleet GWJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.
Kobayashi Y; Graduate School of Pharma-Medical Sciences, University of Toyama, Toyama 930-8555, Japan.
Ikeda H; Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan.
Okada T; Graduate School of Pharma-Medical Sciences, University of Toyama, Toyama 930-8555, Japan.
Toyooka N; Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan.

J Med Chem ; 66(13): 9023-9039, 2023 07 13.

Article en En | MEDLINE | ID: mdl-37314161

Asunto(s)

Enfermedad del Almacenamiento de Glucógeno Tipo II; alfa-Glucosidasas; Humanos; alfa-Glucosidasas/metabolismo; Enfermedad del Almacenamiento de Glucógeno Tipo II/tratamiento farmacológico; Enfermedad del Almacenamiento de Glucógeno Tipo II/genética; Enfermedad del Almacenamiento de Glucógeno Tipo II/metabolismo; Ligandos; Lisosomas/metabolismo; Fibroblastos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Almacenamiento de Glucógeno Tipo II / Alfa-Glucosidasas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google