Atypical tibial fracture in breast cancer patient with bone metastasis receiving denosumab therapy: a case report and review of the literature.
J Med Case Rep
; 17(1): 257, 2023 Jun 21.
Article
en En
| MEDLINE
| ID: mdl-37340320
ABSTRACT
BACKGROUND:
Denosumab therapy is often used to reduce skeletal-related events in metastatic bone disease. On the other hand, there have been some instances of atypical femoral fracture in patients with metastatic bone disease treated with denosumab. In this case report, we describe a patient with metastatic bone disease due to breast cancer who had been using denosumab for 4 years to prevent skeletal-related events and suffered an atypical tibial fracture. CASE PRESENTATION We report here the case of an 82-year-old Japanese woman who had received yearly intravenous denosumab for 4 years and presented with a fracture fulfilling the criteria for an atypical fracture, except for being located at the tibial diaphysis. She was found to have stage 4 breast cancer with multiple bone metastases 4 years prior. She had difficulty walking due to her tibial pain and underwent surgical treatment. Four months after surgery, the tibial fracture site exhibited bone fusion.CONCLUSION:
In patients with long-term use of denosumab to prevent skeletal-related events in metastatic bone disease, it is important to be aware of shin and thigh pain and to examine for signs of atypical tibial fractures to pay attention to atypical femoral fractures.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fracturas de la Tibia
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Neoplasias Óseas
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Neoplasias de la Mama
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Conservadores de la Densidad Ósea
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Fracturas del Fémur
Límite:
Aged80
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Female
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Humans
Idioma:
En
Revista:
J Med Case Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón