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Epigenetic modification in Parkinson's disease.
Song, Hao; Chen, Juanli; Huang, Jin; Sun, Peng; Liu, Yanming; Xu, Li; Wei, Chuanfei; Mu, Xin; Lu, Xianjie; Wang, Wei; Zhang, Nan; Shang, Miwei; Mo, Mei; Zhang, Wei; Zhao, Hui; Han, Fabin.
Afiliación
  • Song H; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
  • Chen J; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Huang J; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Sun P; Laboratory of Basic Medical Research, PLA Strategic Support Force Characteristic Medical Centre, Beijing, China.
  • Liu Y; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
  • Xu L; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Wei C; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Mu X; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Lu X; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Wang W; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Zhang N; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Shang M; The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/The Liaocheng People's Hospital, Liaocheng, Shandong, China.
  • Mo M; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
  • Zhang W; The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
  • Zhao H; Affiliated Yidu Central Hospital, Weifang Medical University, Weifang, China.
  • Han F; Zhengzhou Revogene Scientific Co., LTD., Zhengzhou, Henan, China.
Front Cell Dev Biol ; 11: 1123621, 2023.
Article en En | MEDLINE | ID: mdl-37351278
ABSTRACT
Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD. In this review, we discuss current understanding of the epigenetic mechanisms that regulate gene expression and neural degeneration and then highlight emerging epigenetic targets and diagnostic and therapeutic biomarkers for treating or preventing PD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: China