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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration.
Ortí-Casañ, Natalia; Boerema, Ate S; Köpke, Karina; Ebskamp, Amber; Keijser, Jan; Zhang, Yuequ; Chen, Tingting; Dolga, Amalia M; Broersen, Kerensa; Fischer, Roman; Pfizenmaier, Klaus; Kontermann, Roland E; Eisel, Ulrich L M.
Afiliación
  • Ortí-Casañ N; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands. n.orti.casan@rug.nl.
  • Boerema AS; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Köpke K; Applied Research Center, Van Hall Larenstein University of Applied Science, Leeuwarden, The Netherlands.
  • Ebskamp A; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Keijser J; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Zhang Y; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Chen T; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
  • Dolga AM; Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Broersen K; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
  • Fischer R; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
  • Pfizenmaier K; Applied Stem Cell Technology, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.
  • Kontermann RE; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany.
  • Eisel ULM; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Sci Rep ; 13(1): 10622, 2023 06 30.
Article en En | MEDLINE | ID: mdl-37391534
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Receptores Tipo I de Factores de Necrosis Tumoral / Receptores Tipo II del Factor de Necrosis Tumoral Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Receptores Tipo I de Factores de Necrosis Tumoral / Receptores Tipo II del Factor de Necrosis Tumoral Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos