Oscillatory shear stress-mediated aberrant O-GlcNAc SIRT3 accelerates glycocalyx inflammatory injury via LKB1/p47<sup>phox</sup>/Hyal2 signaling.

Zhang, Lei; Li, Jiajia; Chen, Jun; Lei, Jin; Yuan, Zhiyi; Zhang, Jun; Liu, Zhaohong; Yu, Chao; Ma, Limei

Oscillatory shear stress-mediated aberrant O-GlcNAc SIRT3 accelerates glycocalyx inflammatory injury via LKB1/p47^phox/Hyal2 signaling.

Zhang, Lei; Li, Jiajia; Chen, Jun; Lei, Jin; Yuan, Zhiyi; Zhang, Jun; Liu, Zhaohong; Yu, Chao; Ma, Limei.

Afiliación

Zhang L; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Li J; Hechuan District People's Hospital, Chongqing, China.
Chen J; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Lei J; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Yuan Z; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Zhang J; Institute of Life Sciences, Chongqing Medical University, Chongqing, China.
Liu Z; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China.
Yu C; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China. Electronic address: yuchao@cqmu.edu.cn.
Ma L; Chongqing Key Research Laboratory of Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, China. Electronic address: malimei@cqmu.edu.cn.

Cell Signal ; 109: 110790, 2023 09.

Article en En | MEDLINE | ID: mdl-37392860

Asunto(s)

Aterosclerosis; Sirtuina 3; Humanos; Sirtuina 3/metabolismo; Glicocálix/genética; Glicocálix/metabolismo; Endotelio/metabolismo; Aterosclerosis/metabolismo; Estrés Mecánico; Hialuronoglucosaminidasa/genética; Hialuronoglucosaminidasa/metabolismo; Moléculas de Adhesión Celular/metabolismo; Proteínas Ligadas a GPI/genética

Palabras clave

LKB1/p47(phox)/Hyal2 pathway; O-GlcNAcylation; Oscillatory shear stress; SIRT3; Vascular endothelial glycocalyx

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Sirtuina 3 Límite: Humans Idioma: En Revista: Cell Signal Año: 2023 Tipo del documento: Article País de afiliación: China

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