NLR signaling in plants: from resistosomes to second messengers.
Trends Biochem Sci
; 48(9): 776-787, 2023 09.
Article
en En
| MEDLINE
| ID: mdl-37394345
ABSTRACT
Nucleotide binding and leucine-rich repeat-containing receptors (NLRs) have a critical role in plant immunity through direct or indirect recognition of pathogen effectors. Recent studies have demonstrated that such recognition induces formation of large protein complexes called resistosomes to mediate NLR immune signaling. Some NLR resistosomes activate Ca2+ influx by acting as Ca2+-permeable channels, whereas others function as active NADases to catalyze the production of nucleotide-derived second messengers. In this review we summarize these studies on pathogen effector-induced assembly of NLR resistosomes and resistosome-mediated production of the second messengers of Ca2+ and nucleotide derivatives. We also discuss downstream events and regulation of resistosome signaling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas
/
Proteínas NLR
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
China