Early-life stress contributes to depression-like behaviors in a two-hit mouse model.
Behav Brain Res
; 452: 114563, 2023 08 24.
Article
en En
| MEDLINE
| ID: mdl-37406776
ABSTRACT
BACKGROUND:
Depression is a common psychological disorder with pathogenesis involving genetic and environmental interactions. Early life stress can adversely affect physical and emotional development and dramatically increase the risk for the development of depression and anxiety disorders.METHODS:
To examine potential early life stress driving risk for anxiety and depression, we used a two-hit developmental stress modelï¼injecting poly(I C) into neonatal mice on P2-P6 followed by peripubertal unpredictable stress in adolescence.RESULTS:
Our study shows that early-life and adolescent stress leads to anxiety and depression-related behavioral phenotypes in male mice. Early-life stress exacerbated depression-like behavior in mice following peripubertal unpredictable stress. We confirmed that early life stress might be involved in the decreased neuronal activity in the medial prefrontal cortex (mPFC) and might be involved in shaping behavioral phenotypes of animals. We found that increased microglia and neuroinflammation in the mPFC of two-hit mice and early life stress further boost microglia activation and inflammatory factors in the mPFC region of mice following adolescent stress.LIMITATIONS:
The specific neural circuits and mechanisms by which microglia regulate depression-like behaviors require further investigation.CONCLUSIONS:
Our findings provide a novel insight into developmental risk factors and biological mechanisms in depression and anxiety disorders.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Depresión
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
China