Histologic margin status is a predictor of relapse in lentigo maligna melanoma.
J Am Acad Dermatol
; 89(5): 959-966, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37454699
ABSTRACT
BACKGROUND:
Most surgical margins for lentigo maligna melanomas reported in the literature are clinical and not histologic.OBJECTIVES:
We sought to determine whether histologic margin status is an independent predictor of progression.METHODS:
Clinicopathologic information of 268 invasive lentigo maligna melanomas diagnosed from 1990-2019 were analyzed. Statistical analyses were performed using Cox proportional hazards model and Boruta method.RESULTS:
A total of 75% of the lesions were located on the head and neck. The range of follow-up for all patients was 0 to 31.8 years (median, 10.2 years). Time to local recurrence ranges from 0 to 20 years (median, 3 years). Progression developed in 54 (20.1%) of 268 patients. Local recurrence was seen only in 36 (13.4%), both local recurrence and subsequent metastasis in 7 (2.6%), and only metastasis in 11 (4.1%) of 268 patients. Histologic margin status (positive and close/<3 mm) and tumor site (head and neck location) significantly correlated with worse progression-free survival.LIMITATIONS:
Single institution and retrospective study.CONCLUSIONS:
Histologic margin status is the strongest predictor of progression for lentigo maligna melanoma. Patients with positive or close/<3 mm histologic margins should consider a re-excision due to the increased risk of relapse.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2023
Tipo del documento:
Article