A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes.

Schubert, Laura; Le, Anh T; Hinz, Trista K; Navarro, Andre C; Nelson-Taylor, Sarah K; Nemenoff, Raphael A; Heasley, Lynn E; Doebele, Robert C

Schubert, Laura; Le, Anh T; Hinz, Trista K; Navarro, Andre C; Nelson-Taylor, Sarah K; Nemenoff, Raphael A; Heasley, Lynn E; Doebele, Robert C.

Afiliación

Schubert L; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Le AT; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Hinz TK; Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Navarro AC; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Nelson-Taylor SK; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Nemenoff RA; Departments of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Heasley LE; Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO80045, USA.
Doebele RC; Eastern Colorado VA Healthcare System, Rocky Mountain Regional VA Medical Center, Aurora, CO80045, USA.

Biol Open ; 12(8)2023 08 15.

Article en En | MEDLINE | ID: mdl-37470475

Asunto(s)

Oncogenes; ARN Guía de Sistemas CRISPR-Cas; Animales; Ratones; Inhibidores de Proteínas Quinasas/farmacología

Palabras clave

CRISPR; Gene fusions; Receptor tyrosine kinase; Tyrosine kinase inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / ARN Guía de Sistemas CRISPR-Cas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Biol Open Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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