Your browser doesn't support javascript.
loading
The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells.
Medina Sanchez, Luzmariel; Siller, Magdalena; Zeng, Yanlin; Brigleb, Pamela H; Sangani, Kishan A; Soto, Ariadna S; Engl, Clarisse; Laughlin, Colin R; Rana, Mohit; Van Der Kraak, Lauren; Pandey, Surya P; Bender, Mackenzie J; Fitzgerald, Britney; Hedden, Lee; Fiske, Kay; Taylor, Gwen M; Wright, Austin P; Mehta, Isha D; Rahman, Syed A; Galipeau, Heather J; Mullett, Steven J; Gelhaus, Stacy L; Watkins, Simon C; Bercik, Premysl; Nice, Timothy J; Jabri, Bana; Meisel, Marlies; Das, Jishnu; Dermody, Terence S; Verdú, Elena F; Hinterleitner, Reinhard.
Afiliación
  • Medina Sanchez L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Siller M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Zeng Y; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; School of Medicine, Tsinghua University, Beijing, China.
  • Brigleb PH; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's
  • Sangani KA; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Soto AS; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Engl C; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Laughlin CR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Rana M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Van Der Kraak L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Pandey SP; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Bender MJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Fitzgerald B; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Hedden L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Fiske K; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Taylor GM; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Wright AP; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA.
  • Mehta ID; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Rahman SA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Galipeau HJ; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Mullett SJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
  • Watkins SC; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Bercik P; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Nice TJ; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA.
  • Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Meisel M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  • Das J; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Dermody TS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine,
  • Verdú EF; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Hinterleitner R; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. E
Immunity ; 56(8): 1862-1875.e9, 2023 08 08.
Article en En | MEDLINE | ID: mdl-37478853
ABSTRACT
Loss of oral tolerance (LOT) to gluten, driven by dendritic cell (DC) priming of gluten-specific T helper 1 (Th1) cell immune responses, is a hallmark of celiac disease (CeD) and can be triggered by enteric viral infections. Whether certain commensals can moderate virus-mediated LOT remains elusive. Here, using a mouse model of virus-mediated LOT, we discovered that the gut-colonizing protist Tritrichomonas (T.) arnold promotes oral tolerance and protects against reovirus- and murine norovirus-mediated LOT, independent of the microbiota. Protection was not attributable to antiviral host responses or T. arnold-mediated innate type 2 immunity. Mechanistically, T. arnold directly restrained the proinflammatory program in dietary antigen-presenting DCs, subsequently limiting Th1 and promoting regulatory T cell responses. Finally, analysis of fecal microbiomes showed that T. arnold-related Parabasalid strains are underrepresented in human CeD patients. Altogether, these findings will motivate further exploration of oral-tolerance-promoting protists in CeD and other immune-mediated food sensitivities.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Innata / Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Innata / Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos