Artemeriosides A-F, the first examples of natural sesquiterpenoids substituted by a 6'-O-crontonyl ß-glucopyranoside from Artemisia annua.
Fitoterapia
; 169: 105619, 2023 Sep.
Article
en En
| MEDLINE
| ID: mdl-37487797
ABSTRACT
Artemeriosides A-F (1-6), six novel sesquiterpenoids containing a 6'-O-crontonyl ß-glucopyranoside, were isolated from Artemisia annua L. Their structures were determined by spectral data including HRESIMS, IR, UV, 1D and 2D NMR, and ECD calculations. Compounds 1-6 represented the first examples of natural sesquiterpenoid substituted by 6'-O-crontonyl ß-glucopyranoside. By antihepatoma assay, compounds 1 and 2 demonstrated inhibitory effect against both HepG2 and SK-Hep-1 cells with inhibitory ratios of 77.0%, 88.8%, and 86.8%, 83.9% at 200.0 µM, and compound 1 showed inhibitory activity against Huh7 cells with inhibitory ratio of 56.8%.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
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Artemisia
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Artemisia annua
Idioma:
En
Revista:
Fitoterapia
Año:
2023
Tipo del documento:
Article