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The effect of peppermint oil addition on the physical stability, irritability, and penetration of nanostructured lipid carrier coenzyme Q10.
Erawati, Tristiana; Arifiani, Rizki Amalia; Miatmoko, Andang; Hariyadi, Dewi Melani; Rosita, Noorma; Purwanti, Tutiek.
Afiliación
  • Erawati T; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Arifiani RA; Cosmetics Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Miatmoko A; Bachelor of Pharmacy Study Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Hariyadi DM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Rosita N; Cosmetics Research Group, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Purwanti T; Stem Cell Research and Development Center, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
J Public Health Afr ; 14(Suppl 1): 2515, 2023 Mar 30.
Article en En | MEDLINE | ID: mdl-37492556
Background: Coenzyme Q10 is formulated into Nanostructured Lipid Carrier (NLC) added with peppermint oil (PO) 0% (F1), 1% (F2), 1.5% (F3) and 2% (F4) to increase its penetration. Objective: This study aims to determine the effect of PO addition on the irritability, stability, and penetration of Coenzyme Q10 in the NLC. Methods: Coenzyme Q10 NLC was prepared using the High Shear Homogenization method. Furthermore, physical characterization was carried out. Physical stability testing was carried out for 90 days at a temperature of 25±5oC and an RH of 60±10%. The in vivo irritation test was observed for mice's back skin after 24 hours while the penetration study was further evaluated at 2 hours of the sample application. Results: Increasing the PO amount into Coenzyme Q10 NLC reduced the viscosity which was 329.1±15.5 cps for PO 0% to 219.9±2.9 cps for 2% addition. The observation of particle morphology showed that all NLC Coenzyme Q10 has a spherical particle shape with particle size between 188.25±13.22 to 197.80±14.19 nm. All formulas had high entrapment efficiency (>80%). PO addition did not cause changes in physical characteristics during 90 days of storage. The 24 hours' irritation test showed that F2 and F3 are non-irritating. By PO addition skin penetration improved at 2 hours' penetration study. Conclusion: PO addition up to 2% reduced viscosity, but did not affect particle size and morphology of Coenzyme Q10 NLC. Addition of PO up to 1.5% increased entrapment efficiency, did not irritate and increased the penetration of Coenzyme Q10 NLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Public Health Afr Año: 2023 Tipo del documento: Article País de afiliación: Indonesia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Public Health Afr Año: 2023 Tipo del documento: Article País de afiliación: Indonesia
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