Your browser doesn't support javascript.
loading
Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.
Lauerer, Markus; McGinnis, Julian; Bussas, Matthias; El Husseini, Malek; Pongratz, Viola; Engl, Christina; Wuschek, Alexander; Berthele, Achim; Riederer, Isabelle; Kirschke, Jan S; Zimmer, Claus; Hemmer, Bernhard; Mühlau, Mark.
Afiliación
  • Lauerer M; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • McGinnis J; TUM-Neuroimaging Center, School of Medicine, Technical University, Munich, Germany.
  • Bussas M; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • El Husseini M; Institute for AI in Medicine, Technical University, Munich, Germany.
  • Pongratz V; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • Engl C; TUM-Neuroimaging Center, School of Medicine, Technical University, Munich, Germany.
  • Wuschek A; Department of Neuroradiology, School of Medicine, Technical University, Munich, Germany.
  • Berthele A; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • Riederer I; TUM-Neuroimaging Center, School of Medicine, Technical University, Munich, Germany.
  • Kirschke JS; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • Zimmer C; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • Hemmer B; Department of Neurology, School of Medicine, Technical University, Munich, Germany.
  • Mühlau M; Department of Neuroradiology, School of Medicine, Technical University, Munich, Germany.
J Neurol Neurosurg Psychiatry ; 95(1): 37-43, 2023 Dec 14.
Article en En | MEDLINE | ID: mdl-37495267
BACKGROUND: Spinal cord (SC) lesions have been associated with unfavourable clinical outcomes in multiple sclerosis (MS). However, the relation of whole SC lesion number (SCLN) and volume (SCLV) to the future occurrence and type of confirmed disability accumulation (CDA) remains largely unexplored. METHODS: In this monocentric retrospective study, SC lesions were manually delineated. Inclusion criteria were: age between 18 and 60 years, relapsing-remitting MS, disease duration under 2 years and clinical follow-up of 5 years. The first CDA event after baseline, determined by a sustained increase in the Expanded Disability Status Scale over 6 months, was classified as either progression independent of relapse activity (PIRA) or relapse-associated worsening (RAW). SCLN and SCLV were compared between different (sub)groups to assess their prospective value. RESULTS: 204 patients were included, 148 of which had at least one SC lesion and 59 experienced CDA. Patients without any SC lesions experienced significantly less CDA (OR 5.8, 95% CI 2.1 to 19.8). SCLN and SCLV were closely correlated (rs=0.91, p<0.001) and were both significantly associated with CDA on follow-up (p<0.001). Subgroup analyses confirmed this association for patients with PIRA on CDA (34 events, p<0.001 for both SC lesion measures) but not for RAW (25 events, p=0.077 and p=0.22). CONCLUSION: Patients without any SC lesions are notably less likely to experience CDA. Both the number and volume of SC lesions on MRI are associated with future accumulation of disability largely independent of relapses.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Médula Espinal / Esclerosis Múltiple Recurrente-Remitente / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2023 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Médula Espinal / Esclerosis Múltiple Recurrente-Remitente / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2023 Tipo del documento: Article País de afiliación: Alemania
...