Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation.

Kazyken, Dubek; Lentz, Stephen I; Wadley, Maxwell; Fingar, Diane C

Kazyken, Dubek; Lentz, Stephen I; Wadley, Maxwell; Fingar, Diane C.

Afiliación

Kazyken D; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: dkazyken@umich.edu.
Lentz SI; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Wadley M; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Fingar DC; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: dfingar@umich.edu.

J Biol Chem ; 299(9): 105097, 2023 Sep.

Article en En | MEDLINE | ID: mdl-37507012

Palabras clave

Akt PKB; PI3K; S6 kinase; apoptosis; cell signaling; eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-binding protein; pH regulation; protein synthesis; target of rapamycin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article