Synergistic efficacy of PI3KÎ´ inhibitor with anti-PD-1 mAbs in immune-humanized PDX model of endocrine resistance hormone receptor-positive advanced breast cancer.

Li, Yingjue; Li, Yiwen; Yang, Yu; Deng, Yuwei; Ni, Xiangdong; Zhao, Bochen; Yan, Zhaoqi; He, Wen; Li, Yixin; Li, Shuhui; Liu, Linbo; Lu, Dan

Li, Yingjue; Li, Yiwen; Yang, Yu; Deng, Yuwei; Ni, Xiangdong; Zhao, Bochen; Yan, Zhaoqi; He, Wen; Li, Yixin; Li, Shuhui; Liu, Linbo; Lu, Dan.

Afiliación

Li Y; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Li Y; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Yang Y; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Deng Y; Department of Oncology, Affiliated Oncology Hospital of Harbin Medical University, PR China.
Ni X; Department of Oncology, Hegang People's Hospital, PR China.
Zhao B; Department of Oncology, General Hospital of Shenzhen University, PR China.
Yan Z; Department of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, PR China.
He W; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Li Y; Department of Oncology, Second Affiliated Hospital of Medical College of Shantou University, PR China.
Li S; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Liu L; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.
Lu D; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, PR China.

Heliyon ; 9(8): e18498, 2023 Aug.

Article en En | MEDLINE | ID: mdl-37533997

Palabras clave

Breast cancer (BC); Endocrine therapy resistance; Humanized mice; Immune checkpoint inhibitors; PI3KÎ´ inhibitor; Patient-derived xenograft

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article