Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study.
Geroscience
; 46(1): 57-70, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-37535203
ABSTRACT
Neurofilament light chain (NfL) is a promising biomarker for risk stratification and disease monitoring of dementia, but its utility in the preclinical disease stage remains uncertain. We determined the association of plasma NfL with (change in) neuroimaging markers and cognition in the population-based Rotterdam Study, using linear and logistic regression and mixed-effects models. Plasma NfL levels were measured using the Simoa NF-light™ assay in 4705 dementia-free participants (mean age 71.9 years, 57% women), who underwent cognitive assessment and brain MRI with repeated assessments over a 10-year follow-up period. Higher plasma NfL was associated with worse cognitive performance at baseline (g-factor ß = - 0.12 (- 0.15; - 0.09), p < 0.001), and accelerated cognitive decline during follow-up on the Stroop color naming task (ß = 0.04 (0.02; 0.06), p < 0.001), with a smaller trend for decline in global cognition (g-factor ß = - 0.02 (- 0.04; 0.00), p = 0.044). In the subset of 975 participants with brain MRI, higher NfL was associated with poorer baseline white matter integrity (e.g., global mean diffusivity ß = 0.12 (0.06; 0.19), p < 0.001), with similar trends for volume of white matter hyperintensities (ß = 0.09 (0.02; 0.16), p = 0.011) and presence of lacunes (OR = 1.55 (1.13; 2.14), p = 0.007). Plasma NfL was not associated with volumes or thickness of the total gray matter, hippocampus, or Alzheimer signature regions. In conclusion, higher plasma NfL levels are associated with cognitive decline and larger burden of primarily white matter pathology in the general population.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Disfunción Cognitiva
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Female
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Humans
/
Male
Idioma:
En
Revista:
Geroscience
Año:
2024
Tipo del documento:
Article
País de afiliación:
Países Bajos