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The Cholangiocarcinoma in the Young (CITY) Study: Tumor Biology, Treatment Patterns, and Survival Outcomes in Adolescent Young Adults With Cholangiocarcinoma.
Pappas, Leontios; Baiev, Islam; Reyes, Stephanie; Bocobo, Andrea Grace; Jain, Apurva; Spencer, Kristen; Le, Tri Minh; Rahma, Osama E; Maurer, Jordan; Stanton, Jen; Zhang, Karen; De Armas, Anaemy Danner; Deleon, Thomas T; Roth, Marc; Peters, Mary Linton B; Zhu, Andrew X; Boyhen, Kylie; VanCott, Christine; Patel, Tushar; Roberts, Lewis R; Lindsey, Stacie; Horick, Nora; Lennerz, Jochen K; Iafrate, A John; Goff, Laura Williams; Mody, Kabir; Borad, Mitesh J; Shroff, Rachna T; Javle, Milind M; Kelley, R Katie; Goyal, Lipika.
Afiliación
  • Pappas L; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA.
  • Baiev I; Harvard Medical School, Boston, MA.
  • Reyes S; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA.
  • Bocobo AG; Duke University School of Medicine, Durham, NC.
  • Jain A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
  • Spencer K; Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Le TM; Department of Medicine, NYU Langone Health Perlmutter Cancer Center, NYU School of Medicine, New York, NY.
  • Rahma OE; Department of Medicine, University of Virginia Comprehensive Cancer Center, Charlottesville, VA.
  • Maurer J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Stanton J; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA.
  • Zhang K; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA.
  • De Armas AD; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA.
  • Deleon TT; Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
  • Roth M; Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ.
  • Peters MLB; Department of Medical Oncology, St Luke's Cancer Institute, Kansas City, MO.
  • Zhu AX; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
  • Boyhen K; Jiahui International Cancer Center, Jiahui Health, Shanghai, China.
  • VanCott C; I-MAB Biopharma, Shanghai, China.
  • Patel T; Yale University, New Haven, CT.
  • Roberts LR; Department of Medicine, HCA Florida South Tampa Hospital, Tampa, FL.
  • Lindsey S; Department of Transplantation, Mayo Clinic, Jacksonville, FL.
  • Horick N; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
  • Lennerz JK; The Cholangiocarcinoma Foundation, Herriman, UT.
  • Iafrate AJ; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA.
  • Goff LW; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA.
  • Mody K; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA.
  • Borad MJ; Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, TN.
  • Shroff RT; Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL.
  • Javle MM; Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ.
  • Kelley RK; University of Arizona Cancer Center, University of Arizona, Tucson, AZ.
  • Goyal L; Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
JCO Precis Oncol ; 7: e2200594, 2023 08.
Article en En | MEDLINE | ID: mdl-37561981
PURPOSE: Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes for this population. However, in cholangiocarcinoma (CCA), a paucity of data exist on the AYA population. To our knowledge, we present the largest study to date on AYA disease biology, treatment patterns, and survival outcomes in CCA. METHODS: A multi-institutional cohort of patients with CCA diagnosed with intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC) was used for analysis. Retrospective chart review was conducted on patients who were 50 years old and younger (young; n = 124) and older than 50 years (older; n = 723). RESULTS: Among 1,039 patients screened, 847 patients met eligibility (72% ICC, 28% ECC). Young patients had a larger median tumor size at resection compared with older patients (4.2 v 3.6 cm; P = .048), more commonly had N1 disease (65% v 43%; P = .040), and were more likely to receive adjuvant therapy (odds ratio, 4.0; 95% CI, 1.64 to 9.74). Tumors of young patients were more likely to harbor an FGFR2 fusion, BRAF mutation, or ATM mutation (P < .05 for each). Young patients were more likely to receive palliative systemic therapy (96% v 69%; P < .001), targeted therapy (23% v 8%; P < .001), and treatment on a clinical trial (31% v 19%; P = .004). Among patients who presented with advanced disease, young patients had a higher median overall survival compared with their older counterparts (17.7 v 13.5 months; 95% CI, 12.6 to 22.6 v 11.4 to 14.8; P = .049). CONCLUSION: Young patients with CCA had more advanced disease at resection, more commonly received both adjuvant and palliative therapies, and demonstrated improved survival compared with older patients. Given the low clinical trial enrollment and poor outcomes among some AYA cancer populations, data to the contrary in CCA are highly encouraging.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: JCO Precis Oncol Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: JCO Precis Oncol Año: 2023 Tipo del documento: Article
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