Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report.
World J Clin Cases
; 11(20): 4932-4936, 2023 Jul 16.
Article
en En
| MEDLINE
| ID: mdl-37583994
ABSTRACT
BACKGROUND:
Pulmonary alveolar proteinosis (PAP) often presents nonspecifically and can be easily confused with (1) Idiopathic interstitial lung fibrosis; (2) alveolar carcinoma; (3) pulmonary tuberculosis; and (4) other lung diseases such as viral pneumonia, mycoplasma pneumonia, and chlamydial pneumonia. CASESUMMARY:
Diagnosis In this case, a patient was diagnosed with PAP through transbronchial cryobiopsy (TBCB) and quantitative metagenomic next-generation sequencing, which confirmed the impairment of surfactant turnover as the underlying cause of PAP.Interventions:
High-volume total lung lavage was performed for this patient.Outcomes:
The patient's clinical condition had improved significantly by the 6-month follow-up, with a 92% finger oxygen saturation. A repeat chest computed tomography scan revealed scattered patchy ground-glass shadows in both lungs, which was consistent with alveolar protein deposition but with a lower density than in the radiograph from October 23, 2022.CONCLUSION:
TBCB has unique advantages in diagnosing atypical alveolar protein deposition, particularly for enabling the early detection of PAP. This information can help patients take preventive measures to prevent or halt PAP development by avoiding dusty environments and seeking treatment with total lung lavage and inhaled granulocyte macrophage colony-stimulating factor.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_tuberculosis
Tipo de estudio:
Screening_studies
Idioma:
En
Revista:
World J Clin Cases
Año:
2023
Tipo del documento:
Article
País de afiliación:
China