Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG.

Hayes, Brandon H; Zhu, Hui; Andrechak, Jason C; Dooling, Lawrence J; Discher, Dennis E

Hayes, Brandon H; Zhu, Hui; Andrechak, Jason C; Dooling, Lawrence J; Discher, Dennis E.

Afiliación

Hayes BH; Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhu H; Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrechak JC; Bioengineering Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dooling LJ; Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA.
Discher DE; Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104, USA.

PNAS Nexus ; 2(8): pgad243, 2023 Aug.

Article en En | MEDLINE | ID: mdl-37593202

Palabras clave

CD47; antibodies; macrophages; phagocytosis; titration

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: PNAS Nexus Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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