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Controversies in immunotherapy for anti-NMDA receptor encephalitis: a scoping review with a proposal of operational definitions.
Bandeira, Geovanni Guimarães; Barreto Lima, Pedro Lucas Grangeiro de Sá; Araújo, David Augusto Batista Sá; Pinheiro, Maria Suelly Nogueira; Albuquerque Mota, Luciano de; Simão, Rafael Machado; de Carvalho, Francisco Matheus Oliveira; Vazquez, Fernando Degani; de Vasconcelos Gama, Vitor Carneiro; de Queiroz, Dánton Campos; da Fonseca Lira, Matheus Zaian Rodrigues; de Oliveira Júnior, Pedro Helder; Guimarães Junior, Fernando Antônio; Caminha, Gabrielle Cavalcante; de Figueiredo Santos, Carolina; Sobreira-Neto, Manoel Alves; Braga-Neto, Pedro; Silva, Guilherme Diogo; Nóbrega, Paulo Ribeiro.
Afiliación
  • Bandeira GG; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Barreto Lima PLGS; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Araújo DABS; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Pinheiro MSN; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Albuquerque Mota L; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Simão RM; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • de Carvalho FMO; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Vazquez FD; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • de Vasconcelos Gama VC; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • de Queiroz DC; , Fortaleza, Brazil.
  • da Fonseca Lira MZR; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • de Oliveira Júnior PH; Division of Neurology, Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Guimarães Junior FA; Division of Neurology, Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Caminha GC; Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • de Figueiredo Santos C; Universidade de Fortaleza, Ceara, Fortaleza, Brazil.
  • Sobreira-Neto MA; Hospital Infantil Albert Sabin, Ceara, Fortaleza, Brazil.
  • Braga-Neto P; Núcleo de Tratamento e Estimulação Precoce, Federal University of Ceara, Fortaleza, Brazil.
  • Silva GD; Division of Neurology, Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Nóbrega PR; Division of Neurology, Department of Clinical Medicine, Federal University of Ceara, Fortaleza, Brazil.
Neurol Sci ; 44(12): 4307-4312, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37597088
Anti-NMDA receptor encephalitis (NMDARE), an autoimmune encephalitis associated with autoantibodies against the N-methyl-D-aspartate (NMDA) receptor, affects predominantly young women and is associated with psychiatric symptoms, seizures, movement disorders, and autonomic instability. Traditional treatments of anti-NMDA receptor encephalitis involve corticosteroids, intravenous immunoglobulin, plasmapheresis, cyclophosphamide, and rituximab. However, many controversies remain in the treatment for NMDA receptor encephalitis, such as optimal timing and combination of different immunotherapies, the role of newer strategies (e.g., bortezomib or tocilizumab) for severe and refractory patients, and the need or not for long-term immunosuppression. Our goal was to perform a scoping review to discuss the controversial topics of immunotherapy for NMDA receptor encephalitis and propose operational definitions to guide clinical practice and future research in the field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis Antirreceptor N-Metil-D-Aspartato Tipo de estudio: Systematic_reviews Límite: Female / Humans Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalitis Antirreceptor N-Metil-D-Aspartato Tipo de estudio: Systematic_reviews Límite: Female / Humans Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil
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