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Measurement of Arterial Input Function in Hyperpolarized 13C Studies.
Marjanska, Malgorzata; Teisseyre, Thomas Z; Halpern-Manners, Nicholas W; Zhang, Yi; Iltis, Isabelle; Bajaj, Vikram; Ugurbil, Kamil; Pines, Alexander; Henry, Pierre-Gilles.
Afiliación
  • Marjanska M; Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6 ST SE, Minneapolis, Minnesota 55455, United States.
  • Teisseyre TZ; Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, United States.
  • Halpern-Manners NW; Joint Graduate Group in Bioengineering, UCSF & UC Berkeley, San Francisco, California, United States.
  • Zhang Y; Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, United States.
  • Iltis I; Material Sciences Division, E. O. Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
  • Bajaj V; Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6 ST SE, Minneapolis, Minnesota 55455, United States.
  • Ugurbil K; Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6 ST SE, Minneapolis, Minnesota 55455, United States.
  • Pines A; Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, United States.
  • Henry PG; Material Sciences Division, E. O. Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Appl Magn Reson ; 43(1-2): 289-297, 2012 Jul.
Article en En | MEDLINE | ID: mdl-37601079
ABSTRACT
Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study in vivo metabolism. Injection of hyperpolarized [1-13C]pyruvate, the most widely used substrate, allows detection of time courses of [1-13C]pyruvate and its metabolic products, such as [1-13C]lactate and 13C-bicarbonate, in various organs. However, quantitative metabolic modeling of in vivo data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-13C]pyruvate can be measured in vivo in the rat carotid artery using an implantable coil.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Appl Magn Reson Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Appl Magn Reson Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos