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Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of 18F-FDG-PET.
Zhang, Qi; Fan, Chunqiu; Wang, Luyao; Li, Taoran; Wang, Min; Han, Ying; Jiang, Jiehui.
Afiliación
  • Zhang Q; School of Communication & Information Engineering, Shanghai University, Shanghai, 200444, China.
  • Fan C; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
  • Wang L; School of Life Science, Shanghai University, Shanghai, 200444, China.
  • Li T; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu, 210029, China.
  • Wang M; School of Life Science, Shanghai University, Shanghai, 200444, China.
  • Han Y; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. hanying@xwh.ccmu.edu.cn.
  • Jiang J; School of Biomedical Engineering, Hainan University, Haikou, 570228, China. hanying@xwh.ccmu.edu.cn.
Geroscience ; 46(1): 1407-1420, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37610594
Amyloid-ß (Aß) and tau are important biomarkers to predict the progression of cognitively unimpaired (CU) to dementia due to Alzheimer's disease (AD), according to the diagnosis framework from the US National Institute on Aging and the Alzheimer's Association (NIA-AA). However, it is clinically difficult to predict those subjects who were already with Aß positive (A +) or tau positive (T +). As a typical characteristic of neurodegeneration in the diagnosis framework, the hypometabolism of the posterior cingulate cortex (PCC) has significant clinical value in the early prediction and prevention of AD. In this paper, we proposed the glucose metabolism in the PCC as a biomarker supplement to Aß and tau biomarkers. First, we calculated the standard uptake value ratio (SUVR) of PCC based on fluorodeoxyglucose positron emission computed tomography (FDG PET) imaging. Secondly, we performed Kaplan-Meier (KM) survival analyses to explore the predictive performance of PCC SUVR, and the hazard ratio (HR) was calculated. Finally, we performed Pearson correlation analyses to explore the physiological significance of PCC SUVR. As a result, the PCC SUVR showed a consistent downward trend along the AD continuum. KM analyses showed better predictive performance when we combined PCC SUVR with cerebro-spinal fluid (CSF) Aß42 (from HR = 2.56 to 3.00 within 5 years; from HR = 2.76 to 4.20 within 10 years) and ptau-181 (from 2.83 to 3.91 within 5 years; from HR = 2.32 to 4.17 within 10 years). There was a slight correlation between Aß42/Aß40 and PCC SUVR (r = 0.14, p = 0.02). In addition, several cognition scales were also correlated to PCC SUVR (from r = -0.407 to 0.383, p < 0.05). Our results showed that glucose metabolism in PCC may be a potential biomarker supplement to the Aß and tau biomarkers to predict the progression of CU to AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: China
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