Biomarkers related to silicosis and pulmonary function in individuals exposed to silica.
Am J Ind Med
; 66(11): 984-995, 2023 11.
Article
en En
| MEDLINE
| ID: mdl-37615855
ABSTRACT
BACKGROUND:
The identification of markers that can facilitate the early diagnosis of silicosis has remained challenging. We evaluated the association of inflammatory markers with the presence of silicosis and lung function impairment in individuals exposed to silica.METHODS:
Individuals exposed and not exposed to silica were assessed by occupational history, clinical findings, lung function, chest imaging findings, and inflammatory markers.RESULTS:
Among 297 men evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), and macrophage inflammatory protein-4 (MIP-4) were associated with silicosis, and LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and fibrinogen were negatively associated with lung function.CONCLUSION:
Blood inflammatory markers are associated with silicosis and impaired lung function.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Silicosis
/
Dióxido de Silicio
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Am J Ind Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil