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Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines.
Zhang, Hang; Luo, Qin; He, Yingxin; Zheng, Yajie; Sha, Huiyang; Li, Gan; Kong, Weili; Liao, Jiedan; Zhao, Mengmeng.
Afiliación
  • Zhang H; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Luo Q; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • He Y; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Zheng Y; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Sha H; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Li G; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Kong W; Gladstone Institutes of Virology and Immunology, University of California, San Francisco, CA 94158, USA.
  • Liao J; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
  • Zhao M; School of Life Science and Engineering, Foshan University, Foshan 528000, China.
Vet Sci ; 10(8)2023 Jul 28.
Article en En | MEDLINE | ID: mdl-37624278
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in the pig industry, but its pathogenesis is not yet fully understood. The disease is caused by the PRRS virus (PRRSV), which primarily infects porcine alveolar macrophages and disrupts the immune system. Unfortunately, there is no specific drug to cure PRRS, so vaccination is crucial for controlling the disease. There are various types of single and combined vaccines available, including live, inactivated, subunit, DNA, and vector vaccines. Among them, live vaccines provide better protection, but cross-protection is weak. Inactivated vaccines are safe but have poor immune efficacy. Subunit vaccines can be used in the third trimester of pregnancy, and DNA vaccines can enhance the protective effect of live vaccines. However, vector vaccines only confer partial protection and have not been widely used in practice. A PRRS vaccine that meets new-generation international standards is still needed. This manuscript provides a comprehensive review of the advantages, disadvantages, and applicability of live-attenuated, inactivated, subunit, live vector, DNA, gene-deletion, synthetic peptide, virus-like particle, and other types of vaccines for the prevention and control of PRRS. The aim is to provide a theoretical basis for vaccine research and development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Vet Sci Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Vet Sci Año: 2023 Tipo del documento: Article País de afiliación: China
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