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Ocular manifestations and clinical outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).
Uludag Kirimli, Gunay; Hassan, Muhammad; Onghanseng, Neil; Or, Chris; Yasar, Cigdem; Park, Sungwho; Akhavanrezayat, Amir; Mobasserian, Azadeh; Yavari, Negin; Bazojoo, Vahid; Khojasteh, Hassan; Ghoraba, Hashem; Karaca, Irmak; Trong Tuong Than, Ngoc; Zaidi, Moosa; Nguyen, Quan Dong.
Afiliación
  • Uludag Kirimli G; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Hassan M; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Onghanseng N; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Or C; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Yasar C; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Park S; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Akhavanrezayat A; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Mobasserian A; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Yavari N; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Bazojoo V; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Khojasteh H; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Ghoraba H; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Karaca I; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Trong Tuong Than N; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Zaidi M; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
  • Nguyen QD; Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA. ndquan@stanford.edu.
Eye (Lond) ; 38(2): 349-356, 2024 02.
Article en En | MEDLINE | ID: mdl-37626158
ABSTRACT

PURPOSE:

To describe the various ocular clinical features and visual outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).

METHODS:

The medical records of 13 patients (26 eyes) diagnosed with TINU were reviewed.

RESULTS:

Twenty-six (26) eyes of 13 patients with TINU were reviewed in this study. The median age at onset of uveitis was 14 (range, 9-45). Eight (61.5%) subjects were female. The median follow-up of patients was 30 months (range, 6-89 months). Posterior segment findings were seen in 18 eyes of 9 patients (69.2%). The most common posterior findings were optic nerve head inflammation (16 eyes, 88.8%) and retinal vasculitis (13 eyes, 72.2%). Other posterior findings included vitritis (8 eyes, 44.4%), macular edema (6 eyes, 33.3%), snowball (4 eyes, 22.2%), and chorioretinal lesions (2 eye, 11.1%). Eight patients had fluorescein angiography (FA) data available and most eyes had retinal capillary leakage (13 eyes, 81.2%) followed by optic disc staining/leakage (12 eyes, 75%). Twelve (12) patients (92.3%) were treated with immunomodulatory treatment (IMT) and/or biologics. Five patients (%38.4) required biologics to control intraocular inflammation.

CONCLUSION:

Posterior segment involvement may be common in patients with TINU syndrome. FA provides significant information for detecting posterior segment involvement and disease activity in TINU. The majority of patients required systemic treatment in order to control intraocular inflammation and prevent relapses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Productos Biológicos / Nefritis Intersticial Límite: Female / Humans / Male Idioma: En Revista: Eye (Lond) Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uveítis / Productos Biológicos / Nefritis Intersticial Límite: Female / Humans / Male Idioma: En Revista: Eye (Lond) Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos