The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans.
Trends Neurosci
; 46(11): 953-970, 2023 11.
Article
en En
| MEDLINE
| ID: mdl-37684136
ABSTRACT
Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Gripe Aviar
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Neurosci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Países Bajos