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Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Joyce, Brian T; Chen, Xuefen; Gao, Tao; Zheng, Yinan; Nannini, Drew R; Liu, Lei; Henkle, Benjamin E; Kalhan, Ravi; Washko, George; Kunisaki, Ken M; Thyagarajan, Bharat; Vaughan, Douglas E; Gross, Myron; Jacobs, David R; Lloyd-Jones, Donald; Hou, Lifang.
Afiliación
  • Joyce BT; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Chen X; Department of Epidemiology of Health Statistics, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201318, China.
  • Gao T; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Zheng Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Nannini DR; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Liu L; Division of Biostatistics, Washington University, St. Louis, MO 63110, USA.
  • Henkle BE; Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.
  • Kalhan R; University of Minnesota, Minneapolis, MN 55455, USA.
  • Washko G; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Kunisaki KM; Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  • Thyagarajan B; Minneapolis VA Health Care System, Minneapolis, MN 55417, USA.
  • Vaughan DE; University of Minnesota, Minneapolis, MN 55455, USA.
  • Gross M; University of Minnesota, Minneapolis, MN 55455, USA.
  • Jacobs DR; Potocsnak Longevity Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Lloyd-Jones D; University of Minnesota, Minneapolis, MN 55455, USA.
  • Hou L; University of Minnesota, Minneapolis, MN 55455, USA.
Epigenomics ; 15(13): 693-703, 2023 07.
Article en En | MEDLINE | ID: mdl-37694401
ABSTRACT

Background:

The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema.

Methods:

This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined.

Results:

At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20.

Conclusion:

Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Coronarios / Enfisema Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Epigenomics Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Coronarios / Enfisema Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Epigenomics Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos