Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus.
Signal Transduct Target Ther
; 8(1): 350, 2023 09 15.
Article
en En
| MEDLINE
| ID: mdl-37709783
ABSTRACT
The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. The vaccinia virus Tiantan strain (VTT) was used to vaccinate against smallpox in China 42 years ago. It is urgent to assess the level of immunity to smallpox in individuals vaccinated 43 or more years ago and evaluate their immunological susceptibility to MPXV. Here, we recruited 294 volunteers and detected the level of residual humoral immunity, including the vaccinia-specific IgG level and neutralizing antibody titer, and the cross-antibodies of MPXV A29L, B6R, A35R, and M1R. Our results showed that the humoral immunity from the smallpox vaccine in the population still remains, and VTT-specific NAb levels wane with age. The majority of the population pre-1981 who should be immunized with VTT still maintains certain levels of MPXV-specific antibodies, in particular, targeting A35R and B6R antigens. Furthermore, we separately analyzed the correlations between the OD450 values of VTT-specific IgG and A35R-specific IgG, B6R-specific IgG, and A29L-specific IgG with plasma samples diluted 140, showing a linear correlation (p < 0.0001). Our findings suggest that most Chinese populations still maintain VTT-specific IgG antibodies for 42 or more years after smallpox vaccination and could provide some level of protection against MPXV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
10_ODS3_salud_sexual_reprodutiva
/
2_ODS3
/
4_TD
Problema de salud:
10_sexually_transmitted_infections
/
2_cobertura_universal
/
2_enfermedades_transmissibles
/
4_smallpox
Asunto principal:
Vacuna contra Viruela
/
Mpox
/
Inmunidad Humoral
Límite:
Humans
Idioma:
En
Revista:
Signal Transduct Target Ther
Año:
2023
Tipo del documento:
Article
País de afiliación:
China