Paraformaldehyde as C1 Synthon: Electrochemical Three-Component Synthesis of Tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones in Aqueous Ethanol.

Lu, Yu-Han; Mu, Si-Yu; Jiang, Jun; Zhou, Min-Hang; Wu, Chao; Ji, Hong-Tao; He, Wei-Min

Lu, Yu-Han; Mu, Si-Yu; Jiang, Jun; Zhou, Min-Hang; Wu, Chao; Ji, Hong-Tao; He, Wei-Min.

Afiliación

Lu YH; Hengyang Medical School, University of South China, Hengyang, 421001, China.
Mu SY; Hengyang Medical School, University of South China, Hengyang, 421001, China.
Jiang J; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.
Zhou MH; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.
Wu C; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.
Ji HT; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.
He WM; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China.

ChemSusChem ; 16(19): e202300523, 2023 Oct 06.

Article en En | MEDLINE | ID: mdl-37728196

RESUMEN

A green and practical method for the electrochemical synthesis of tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones through the three-component reaction of quinoxalin-2(1H)-ones, N-arylglycines and paraformaldehyde was reported. In this strategy, EtOH played dual roles (eco-friendly solvent and waste-free pre-catalyst) and the inâsitu generated ethoxide promoted triple sequential deprotonations.

Palabras clave

electro-organic synthesis; ethanol; multicomponent reaction; paraformaldehyde; quinoxalin-2(1H)-ones

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ChemSusChem Asunto de la revista: QUIMICA / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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