Protocol for the synthesis of homoallenic alcohols via allenyl radical-mediated allenylation of alkenes.
STAR Protoc
; 4(4): 102598, 2023 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-37756157
ABSTRACT
Homoallenic alcohols are versatile building blocks to access complex molecules in synthetic chemistry. We present a protocol for accessing homoallenic alcohols by an allenyl radical-involved radical-polar crossover process. We describe steps for preparing solvents and the photoreactor and synthesizing 5-methyl-1-phenyl-3-tosylhexa-3,4-dien-1-ol 3 in 85% yield. In addition, 5-methyl-1-phenyl-3-tosylhexa-3,4-dien-1-ol 3 has been successfully synthesized in 2-mmol scale. This protocol is also applicable to the synthesis of homoallenic amides. For complete details on the use and execution of this protocol, please refer to Wei et al. (2023).1.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alcoholes
/
Alquenos
Idioma:
En
Revista:
STAR Protoc
Año:
2023
Tipo del documento:
Article