Microviruses: A World Beyond phiX174.
Annu Rev Virol
; 10(1): 99-118, 2023 09 29.
Article
en En
| MEDLINE
| ID: mdl-37774127
ABSTRACT
Two decades of metagenomic analyses have revealed that in many environments, small (â¼5 kb), single-stranded DNA phages of the family Microviridae dominate the virome. Although the emblematic microvirus phiX174 is ubiquitous in the laboratory, most other microviruses, particularly those of the gokushovirus and amoyvirus lineages, have proven to be much more elusive. This puzzling lack of representative isolates has hindered insights into microviral biology. Furthermore, the idiosyncratic size and nature of their genomes have resulted in considerable misjudgments of their actual abundance in nature. Fortunately, recent successes in microvirus isolation and improved metagenomic methodologies can now provide us with more accurate appraisals of their abundance, their hosts, and their interactions. The emerging picture is that phiX174 and its relatives are rather rare and atypical microviruses, and that a tremendous diversity of other microviruses is ready for exploration.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacteriófagos
/
Microviridae
Idioma:
En
Revista:
Annu Rev Virol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos