Your browser doesn't support javascript.
loading
From Its Nature to Its Function: Marine-Collagen-Based-Biomaterials for Hard Tissue Applications.
Diogo, Gabriela S; Pirraco, Rogério P; Reis, Rui L; Silva, Tiago H.
Afiliación
  • Diogo GS; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Portugal.
  • Pirraco RP; ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal.
  • Reis RL; 3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Portugal.
  • Silva TH; ICVS/3B's - PT Government Associate Laboratory, Braga, Portugal.
Article en En | MEDLINE | ID: mdl-37776181
ABSTRACT
Rapidly growing demand for collagen-based therapeutic applications requires a great amount of collagen stock. Commercial collagen is mainly confined to mammalian sources, which have concerns about zoonotic disease transfer and, additionally, the problem of terrestrial animals' overexploitation, which, even so, does not meet the crescent demand for collagen. The extraction of collagen from marine organisms, including the wastes of vertebrates and invertebrates, has both economic and environmental benefits. Marine collagen (MC) is easy to extract, has excellent biocompatibility and good absorption properties, is low in zoonotic and immunological risks for patients, and has fewer religious and regulatory restrictions. This review discusses the research done using MC on biomaterials for bone, cartilage, and osteochondral tissue regenerative applications and the underlying technologies that enable their development. The main challenges on processing MC associated with specific features, such as the low denaturation temperature and weak mechanical properties, are also addressed. A combination of blends and physical or chemical crosslinking treatments with conventional processing methodologies is still traditionally used to prepare MC biomaterials. However, the growing role of MC in the health care-related field, particularly in the treatment of musculoskeletal defects, has been pushing the scientific community to explore advanced techniques to design and develop safe, yet functional materials to better meet tissues' functionality.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Tissue Eng Part B Rev Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Portugal

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Tissue Eng Part B Rev Asunto de la revista: BIOTECNOLOGIA / HISTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Portugal
...