Role of MicroRNAs in Dietary Interventions for Obesity and Obesity-Related Diseases.
J Agric Food Chem
; 71(40): 14396-14412, 2023 Oct 11.
Article
en En
| MEDLINE
| ID: mdl-37782460
ABSTRACT
Obesity and related metabolic syndromes pose a serious threat to human health and quality of life. A proper diet is a safe and effective strategy to prevent and control obesity, thus maintaining overall health. However, no consensus exists on the connotations of proper diet, and it is attributed to various factors, including "nutritional dark matter" and the "matrix effect" of food. Accumulating evidence confirms that obesity is associated with the in vivo levels of miRNAs, which serve as potential markers and regulatory targets for obesity onset and progression; food-derived miRNAs can regulate host obesity by targeting the related genes or gut microbiota across the animal kingdom. Host miRNAs mediate food nutrient-gut microbiota-obesity interactions. Thus, miRNAs are important correlates of diet and obesity onset. This review outlines the recent findings on miRNA-mediated food interventions for obesity, thereby elucidating their potential applications. Overall, we provide new perspectives and views on the evaluation of dietary nutrition, which may bear important implications for dietary control and obesity prevention.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
MicroARNs
/
Microbioma Gastrointestinal
Aspecto:
Patient_preference
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Agric Food Chem
Año:
2023
Tipo del documento:
Article