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Leveraging existing 16S rRNA microbial data to identify diagnostic biomarker in Chinese patients with gastric cancer: a systematic meta-analysis.
Chen, Jijun; Nie, Siru; Qiu, Xunan; Zheng, Shuwen; Ni, Chuxuan; Yuan, Yuan; Gong, Yuehua.
Afiliación
  • Chen J; Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Nie S; Key Laboratory of Cancer Etiology and Prevention, Liaoning Education Department, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Qiu X; Key Laboratory of GI Cancer Etiology and Prevention, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Zheng S; Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Ni C; Key Laboratory of Cancer Etiology and Prevention, Liaoning Education Department, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Yuan Y; Key Laboratory of GI Cancer Etiology and Prevention, The First Hospital of China Medical University , Shenyang, Liaoning, China.
  • Gong Y; Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University , Shenyang, Liaoning, China.
mSystems ; 8(5): e0074723, 2023 Oct 26.
Article en En | MEDLINE | ID: mdl-37787561
ABSTRACT
IMPORTANCE Gastric cancer is a significant and growing health problem in China. Studies have revealed significant differences in gastric microbiota between patients with gastric cancer and non-cancerous patients, suggesting that microbiota may play a role in tumorigenesis. In this meta-analysis, existing 16S rRNA microbial data were analyzed to find combinations consisting of five genera, which had good efficacy in distinguishing gastric cancer from non-cancerous patients in multiple types of samples. These results lend support to the use of microbial markers in detecting gastric cancer. Moreover, these biomarkers are plausible candidates for further mechanistic research into the role of the microbiota in tumorigenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Neoplasias Gástricas / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: MSystems Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_zoonosis Asunto principal: Neoplasias Gástricas / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans País/Región como asunto: Asia Idioma: En Revista: MSystems Año: 2023 Tipo del documento: Article País de afiliación: China