Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency.

Lorton, Benjamin M; Warren, Christopher; Ilyas, Humaira; Nandigrami, Prithviraj; Hegde, Subray; Cahill, Sean; Lehman, Stephanie M; Shabanowitz, Jeffrey; Hunt, Donald F; Fiser, Andras; Cowburn, David; Shechter, David

Lorton, Benjamin M; Warren, Christopher; Ilyas, Humaira; Nandigrami, Prithviraj; Hegde, Subray; Cahill, Sean; Lehman, Stephanie M; Shabanowitz, Jeffrey; Hunt, Donald F; Fiser, Andras; Cowburn, David; Shechter, David.

Afiliación

Lorton BM; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Warren C; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Ilyas H; Current address: Merck & Co., Inc., 2025 E Scott Ave., Rahway, NJ 07065.
Nandigrami P; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Hegde S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Cahill S; Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Lehman SM; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Shabanowitz J; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.
Hunt DF; Department of Chemistry, University of Virginia, Charlottesville, VA 22904.
Fiser A; GSK, Collegeville, Pennsylvania 19426.
Cowburn D; Department of Chemistry, University of Virginia, Charlottesville, VA 22904.
Shechter D; Department of Chemistry, University of Virginia, Charlottesville, VA 22904.

bioRxiv ; 2023 Sep 19.

Article en En | MEDLINE | ID: mdl-37790377

Palabras clave

DNA replication; IDR; MD; N1; NAP1L1; NASP; NMR; Nap1; Npm2; TTLL4; acidic IDR; acidic stretch; chromatin; epigenetics; farnesylation; glutamate-glutamylation; glutamylation; histone chaperone; molecular dynamics; nuclear magnetic resonance; nucleosome; nucleus; polyelectrolyte

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article