Efficient macrocyclization facilitated by skeleton preorganization.

Xu, Rong-Yao; Liu, Xiu; Sun, Guang; Zhang, Zhi-Yuan; Dong, Ming; Zhao, Liya; Zhang, Si-Miao; Wang, Xi-Yang; Zhang, Hong-Xu; Yang, Shang-Jie; Wang, Xiuguang; Li, Bin; Li, Jian; Li, Chunju

Xu, Rong-Yao; Liu, Xiu; Sun, Guang; Zhang, Zhi-Yuan; Dong, Ming; Zhao, Liya; Zhang, Si-Miao; Wang, Xi-Yang; Zhang, Hong-Xu; Yang, Shang-Jie; Wang, Xiuguang; Li, Bin; Li, Jian; Li, Chunju.

Afiliación

Xu RY; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Liu X; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Sun G; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Zhang ZY; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Dong M; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Zhao L; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Zhang SM; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Wang XY; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Zhang HX; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Yang SJ; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Wang X; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Li B; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.
Li J; School of Chemistry and Chemical Engineering, Henan Normal University P. R. China.
Li C; Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University Tianjin 300387 P. R. China zzy@tjnu.edu.cn hxxydongm@tjnu.edu.cn cjli@tjnu.edu.cn.

RSC Adv ; 13(43): 30269-30272, 2023 Oct 11.

Article en En | MEDLINE | ID: mdl-37881211

ABSTRACT

ABSTRACT

Reported here is the efficient macrocyclization facilitated by skeleton preorganization. A pyridylcarbazole macrocycle and a phenylpyridylcarbazole macrocycle was synthesized in yield up to 75%. Single-crystal structures and theoretic computation uncovered that the skeleton preorganization promoted the formation of cyclization-favorable conformation of noncyclic precursors via πâ¯π interactions. This result provided a new approach for the efficient syntheses of macrocycles.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2023 Tipo del documento: Article